![malvern zetasizer ns malvern zetasizer ns](https://www.labmate-online.com/assets/file_store/pr_files/26910/thumbnails/images/391w_mal_job_2708_image.jpg)
![malvern zetasizer ns malvern zetasizer ns](https://www.atascientific.com.au/wp-content/uploads/2018/05/2018-05-25_145041.jpg)
The in vitro effect on proliferation and cellular senescence (beta galactosidase assay) in long term culture was assessed. Methods: Human primary ADSC and WJMSC from various donors were loaded with proprietary uncoated MNP. In this study, we investigated comparatively chondrogenic conversion of ADSC-MNP and WJMSC with or without MF exposure in order to identify the most appropriate cell source and differentiation protocol for future cartilage engineering strategies. Magnetic field (MF) exposure of MNP-loaded ADSC has been proposed as a method to deliver mechanical stimulation for increasing conversion to musculoskeletal lineages. Their superiority compared to other mesenchymal stem cell consists in larger availability, and superior proliferative and differentiation potential.
![malvern zetasizer ns malvern zetasizer ns](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41598-021-97224-4/MediaObjects/41598_2021_97224_Fig1_HTML.png)
Adipose derived mesenchymal stem cells (ADSC) and Wharton Jelly mesenchymal stem cells (WJMSC) are currently tested in different strategies for regenerative regenerative medicine (RM) purposes. Purpose: Iron oxide based magnetic nanoparticles (MNP) are versatile tools in biology and medicine. 4Pathology Department County Children Emergency Hospital Saint Mary, Iasi, Romania.3Faculty of Physics, Alexandru Ioan Cuza University, Iasi, Romania.2Orthopedics and Traumatology Clinic County Emergency Hospital Saint Spiridon, Iasi, Romania.1National Institute of Research and Development for Technical Physics, Iasi, Romania.Luminita Labusca 1,2, Dumitru-Daniel Herea 1*, Anca Emanuela Minuti 1,3, Cristina Stavila 1,3, Camelia Danceanu 1,3, Petru Plamadeala 4, Horia Chiriac 1 and Nicoleta Lupu 1